DelveInsight’s, “Nasopharyngeal Cancer Pipeline Insight 2024” report provides comprehensive insights about 25+ companies and 30+ pipeline drugs in Nasopharyngeal Cancer pipeline landscape. It covers the Nasopharyngeal Cancer pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Nasopharyngeal Cancer therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
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Key Takeaways from the Nasopharyngeal Cancer Pipeline Report
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Nasopharyngeal Cancer Emerging Drugs Profile
BL-B01D1 is a first-in-class bispecific antibody-drug conjugate (ADC) developed by SystImmune, targeting both EGFR and HER3, proteins that are highly expressed in most epithelial tumors. The tetravalent BL-B01D1 possesses two binding domains blocking each Growth Factor Receptor, which both drive cancer cell proliferation and survival. Inheriting the SI-B001 mechanisms of action, BL-B01D1 effectively blocks EGFR and HER3 signals to cancer cells, thereby reducing proliferation and survival signals. Upon antibody-mediated internalization, BL-B01D1 is trafficked to cancer cell lysosomes and liberates its therapeutic payload that induced genotoxic stress activating pathways leading to cancer cell death. Currently, the drug is in Phase III stage of its clinical trial for the treatment of nasopharyngeal Carcinoma.
TAK-500 is a first-in-class STING agonist immunostimulatory antibody drug conjugate (iADC) that delivers dazostinag to CCR2+ myeloid cells in the tumor microenvironment. By targeting the STING pathway and CCR2 expressing myeloid cells, TAK-500 may offer enhanced potency via improved PK and selective delivery. TAK-500 has three possible mechanisms of action: activation of IFN response, reprogramming of suppressive intratumoral CCR2+ myeloid cells, and blockade of suppressive tumor-associated macrophage recruitment. Currently, the drug is in Phase I/II stage of its clinical trial for the treatment of nasopharyngeal cancer.
APG-5918 is under development for the treatment of beta-thalassemia, metastatic solid tumors or relapsed or refractory non-Hodgkin’s Lymphoma, nasopharyngeal carcinoma, castration-resistant prostate cancer, B-cell non-Hodgkin lymphoma, IN1-negative malignant rhabdoid tumor, gastric cancer, ovarian clear cell carcinoma, mesothelioma, b cell lymphoma, sickle cell disease, diffuse large B cell lymphoma (DLBCL), SMARCB1-deficient malignant rhabdoid tumor,solid tumor, hematological tumor, anemia and unspecified indication. It is administered through oral route. It acts by targeting polycomb protein EED. Currently, the drug is in Phase I stage of clinical trial for the treatment of nasopharyngeal Carcinoma.
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Nasopharyngeal Cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration.
Nasopharyngeal Cancer Products have been categorized under various Molecule types such as
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Scope of the Nasopharyngeal Cancer Pipeline Report
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